It's common for people with Parkinson's to get depression but not everyone with the condition will experience it.

With the right help, support and treatment you can overcome depression and enjoy a good quality of life.

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Depression is usually diagnosed when someone has feelings of extreme sadness or a sense of emotional 'emptiness' for a long time. It's more than a temporary feeling of sadness, unhappiness or frustration.

These feelings may affect someone's ability to carry out day-to-day activities.

A person who is depressed will typically have one or more of these symptoms:

  • lack of interest in, or pleasure from, usual activities
  • feeling down or hopeless nearly every day
  • feeling anxious, fearful or constantly worried

It's rare to experience all of the following symptoms, but if you're depressed you might also have:

  • difficulty concentrating
  • low energy and feelings of tiredness
  • trouble sleeping (waking in the early hours of the morning can be a typical sign) or problems with excessive sleeping
  • a loss of appetite, usually connected with weight loss
  • increased appetite and weight gain
  • feelings of worthlessness or guilt
  • thoughts of death, suicide or self-harm, in severe cases

Like any illness, depression can affect anyone at any time. It's no one's fault, and it is not a sign of weakness.

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Some of the symptoms of depression are also common in Parkinson's, which means it is often difficult to diagnose.

For example, many people with Parkinson's experience sleep and night-time problems. These difficulties will probably make you feel tired and lacking in energy, but they don't necessarily mean you're depressed.

Fatigue, which is an overwhelming sense of tiredness, can also be a symptom of both Parkinson's and depression.

You may experience ups and downs in your mood because of the changing nature of your Parkinson's symptoms throughout the day. These changes in mood aren't necessarily a sign of depression.

In some cases, these feelings may be related to changes in your Parkinson's medication.

With this in mind, if you think you may be depressed it's very important to speak to your GP or specialist. They can make an accurate diagnosis and discuss your medication with you.

Severe depression may result in suicidal thoughts or plans. It may also disrupt a person's sense of reality or make it much harder for them to function on a day-to-day basis. This requires very specific treatment by a mental health specialist.

Speak to your GP, specialist or Parkinson's nurse if you have any concerns.

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We don't know for sure why people with Parkinson's get depression. There are several possible explanations.

Some research has suggested that a lack of the chemical dopamine, which causes the symptoms of Parkinson's, can be a trigger for depression, worry and anxiety.

Depression can be related to genetics. So if you have a family history of depression, you are more likely to experience depression yourself.

Being diagnosed with Parkinson's can be very stressful and upsetting for many reasons, and the condition can have an impact on every aspect of life. It's completely understandable that you might sometimes experience feelings of depression because of Parkinson's.

For example, as Parkinson's symptoms progress, some people may find that they can't spend as much time on certain activities, such as socialising. This could lead to loneliness and isolation, which may increase the risk of depression.

In some cases people have experienced depression months before they notice any Parkinson's symptoms.

Depression can also be part of non-motor fluctuations. This links to the effect of levodopa ‘wearing off’ before the next dose is due. This type of depressed mood or anxiety usually gets better after the next dose of levodopa starts working.

Other causes of depression-like symptoms

Whether or not you have Parkinson's, depression could be linked to other physical conditions. These could include nutritional diet deficiencies such as low vitamin B12, B9 (folate levels) or anaemia. Depression can also be linked to thyroid problems.

Speak to your GP, specialist or Parkinson's nurse if you have any concerns.

It may also be possible that you are undermedicated for the motor symptoms of Parkinson's.

Depression could be a side effect of any other drugs you are taking.

Alcohol can also be a depressant, so drinking too much can cause low moods and affect your sleeping pattern. If you have any questions or concerns, speak to your GP, who can make sure you get the right support.


Apathy is being increasingly recognised in Parkinson's. It is described as a lack of enthusiasm and emotion for everyday activities. This can feel like depression. Unlike depression though, apathy is not linked to low self-esteem or a negative outlook on the future. So just because you are experiencing apathy does not mean you have depression.

Apathy needs to be diagnosed so it can be treated. A mental health specialist or counsellor will be able to provide you with the best advice.

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Treating Parkinson's symptoms to help your depression

The first step is to talk to your GP, specialist or Parkinson's nurse to make sure your Parkinson's drugs are working well. It is important that your treatment is tailored specifically to you.

Treatment will depend on how severe your symptoms are and what has helped in the past. Treatments should be introduced step by step, starting with the simplest self-help measures.

After your Parkinson's medication is adjusted appropriately, depression may be treated.

There is some limited evidence to suggest that some dopamine agonists – for example, bromocriptine or pramipexole (Mirapexin) – may improve a person's mood as well as any mobility problems. But there can be side effects, so this treatment might not be an option for everyone.

What can I do about depression to help myself?

Although you should get advice from mental health professionals, there are a number of things you can do yourself that may help improve your mood.

One recommended way of helping mild depression is to understand it better.

Try contacting the organisations in our useful contacts section. Some produce guides or recommend books about how you can help yourself to manage depression. Others offer helpline services for you to talk to someone about your feelings or get help.

Other types of self-help include:

Exercise - Exercise is good for you if you have Parkinson’s and it can be as important as your medication in helping you manage your symptoms. In fact, research has shown that exercising two to three times a week, especially as part of a group, can help with depression.

It can also boost your mood and help you sleep well. So find something that suits you and go for it. This could be as simple as chair-based exercise or a brisk walk that gets your heart rate up.

To get started, a physiotherapist can recommend exercise that is right for you. Also, exercise referral schemes may be organised in your local area through your GP, local council or sports centre.

Find out more about the benefits of exercise and different types to focus on.

Sleep – To help improve the amount and quality of your sleep, make sure your bedroom is quiet and comfortable. Try to go to bed at the same time each night.

Relaxation – You may find relaxation therapies, such as aromatherapy, useful. Although there is limited evidence that they can help with depression.

You could try complementary therapies such as massage, exercises such as tai chi or yoga, or meditation.

Self-help computer programmes – Some GPs provide access to computerised cognitive behavioural therapy courses. You will go through the same type of session as you would if you were with a therapist.

Beating The Blues is a commonly used one. There is also an online course, MoodGYM, which you may find helpful.

If you are interested in any of these activities, speak to your GP about what may be suitable for you and about getting a referral.

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If self-help measures do not improve your symptoms, or if your depression is severe, your GP may recommend a course of talking therapy. This includes counselling and cognitive behavioural therapy.

Cognitive behavioural therapy (CBT)

For persistent or significant depression, group or individual therapy using cognitive behavioural techniques can be useful. Cognitive behavioural therapy usually involves a course of weekly sessions.

This is a therapy designed to change your emotions and lift depression. It looks at how you think about yourself, your environment and the people around you, and how these thoughts affect your mood and behaviour.

Your therapist will try to teach you new skills to help deal with negative thoughts and problems more effectively. They may use techniques including relaxation, distraction and goal setting.


A professional counsellor can work with you to understand any underlying issues that may be contributing to your depression.

Counsellors may also be trained in other psychological therapies and could possibly apply different techniques.

Before choosing a professional, it's always a good idea to ask about their qualifications and experience. Some GP practices have a counsellor, or you can be referred to one by your GP, specialist or nurse.

If you want to make your own enquiries about cognitive behaviour therapy or counselling services in your area, you could try contacting the British Psychological Society or the British Association for Counselling and Psychotherapy.


Antidepressants are medications that can be used to treat moderate to severe depression. They may be prescribed alone, or alongside a course of talking therapy.

There are 3 main types of antidepressant, and they work by stimulating chemicals in the brain. If your GP or specialist thinks that antidepressants are right for you, they will able to talk through your options.

It’s important to remember that some antidepressants will be more suitable for you than others – it depends on your symptoms and what other medications you're taking.

Your specialist will also be able to advise you on how to take antidepressants alongside your Parkinson’s medication. Taking antidepressants won't always improve your mood immediately. It may take 2 to 4 weeks before you notice any change in your symptoms.

As with most medications, antidepressants can have side effects, but they are generally safe.

There is no evidence that antidepressants are addictive, although some people may experience symptoms such as irritability or nausea when they stop taking them.

You can speak to the professional prescribing your medication if you have any concerns about the potential side effects. They should also be able to advise you on how to take antidepressants alongside your Parkinson's medication.

It is very important that you take antidepressants as prescribed, even if you feel better.

Treatment should normally continue for six months after your symptoms improve, but may need to be for longer, depending on your health professional's advice.

There is no evidence of any long-term side effects from staying on antidepressants.

St John’s Wort

Be aware that the herbal remedy St John's Wort, which can be used for depression, is not recommended for people with Parkinson's. This is because St John’s Wort can interact with your Parkinson’s drugs.

St John’s Wort is also often mixed with other components to create different brands of the herbal remedy. This could increase the possibility of side effects and interactions.

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Some people find it useful to talk to others who have been in a similar situation.               

Support groups allow you to share problems and experiences. Group members can offer understanding based on what has helped them in the past, which you may find useful.

Parkinson's UK has local groups across the UK that offer friendship and support. 

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If you care for someone who has Parkinson’s and depression, you may want to think about support for yourself too.

It's important for family, friends and carers to recognise that the mood of someone with Parkinson’s can negatively affect their own emotions.

If untreated, depression may continue for many years, so it's important to recognise it and get help.

Sometimes a carer, or someone close to a person with Parkinson's, may recognise the symptoms of depression more clearly than the person themselves. If this is the case, they should talk about their concerns with the person's GP, specialist or Parkinson's nurse.

It is also quite normal for a carer to feel many of the same feelings as the person with Parkinson's.

These feelings may include difficulty accepting the diagnosis, fear about the future, anxiety, depression and fatigue. They might also experience confusion about the changes to their role and their relationship with the person they care for.

Because of this, carers should try to look after their physical and mental health as much as they can. This will help them maintain their caring role.

This can be difficult, but it's important to remember that by taking care of their own health, they will be better able to care for the person with Parkinson's.

Many carers find it helpful to join a support group, where they can meet other people in a similar situation. Carers UK and the Princess Royal Trust for Carers both run groups for carers.

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  • Samaritans - If you need someone to talk to, the Samaritans provides a place for you to explore your feelings in confidence and without prejudice.
  • Mental Health Foundation - The organisation produces a range of information, booklets and podcasts on mental health problems including depression.
  • Mind - A leading mental health organisation serving people in England and Wales. The charity provides support and advice on all kinds of mental health problems, including depression. It has a range of publications and local support groups.
  • The Scottish Association for Mental Health - Provides information and support for people living in Scotland,
  • Carers UK - Provides information and support to people who are caring at home. The charity has support groups, branches and local offices throughout the UK.
  • Carers Trust  - Provides support, information and centres for carers throughout the UK and most centres run carers' groups.
  • Breathing Space - A free, confidential phone and web-based service for people (especially young men) in Scotland experiencing low mood, depression or anxiety.
  • British Psychological Society - This organisation can help you find a clinical or counselling psychologist in your area.
  • British Association for Counselling and Psychotherapy - You can find contact details for local counsellors and psychotherapists on their website.
  • Aware Defeat Depression - Provides support to people living with depression in Northern Ireland.

Download PDF or order a printed copy

Depression and Parkinson's (PDF, 165KB)

Iselder a chlefyd Parkinson (PDF, 531KB)

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“I was really reluctant about antidepressants at first. I had really bad drowsiness but I ended up persevering. After a few weeks it all settled, and I even managed to go back to work.”

Julia shares her story of living with Parkinson’s and depression, and the coping strategies she uses to improve her mood.


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"Your mind gets down there and it's hard to get back up"

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Sharon talks about being depressed after her diagnosis and how volunteering gave her something positive to focus on.

Mindfulness and Parkinson's

Practising mindfulness can help with mental health symptoms like anxiety and depression. We've developed a series of videos and an audio session to guide you through some basic mindfulness techniques.

Helpline and local advisers

Our helpline and Parkinson's local advisers are here to answer any questions you have about depression.

Call us on 0808 800 0303.

Last updated December 2017. We review all our information within 3 years. If you'd like to find out more about how we put our information together, including references and the sources of evidence we use, please contact us at [email protected]