Dyskinesia and wearing off

If you’ve been taking a Parkinson’s drug that contains levodopa – for example, co-beneldopa or co-careldopa – for some time, you may develop motor fluctuations, wearing off and dyskinesia. These are side effects that can affect your movement.

Wearing off

Wearing off happens when the Parkinson's medication you've been taking is no longer working as effectively as it used to. Because of this, your Parkinson's symptoms may return towards the end of a medication dose, or near the beginning of your next dose.

If these symptoms are affecting your day-to-day life, then your specialist or Parkinson's nurse should review your medication.

In the early stages of Parkinson's, you may not notice when a dose of levodopa begins to wear off. But as Parkinson's progresses, some people find that a dose doesn't last as long as it used to, so changes can become more unpredictable.

As well as having an effect on your movement, you may also experience feelings of anxiety, sleepiness, low mood or pain as your medication wears off.

Being 'on' or 'off' is different from 'freezing'.

If a person's symptoms are well controlled, this is known as the 'on' period, which means that medication is working well. When symptoms return, this is known as the 'off' period.

This might mean that a person who is out for a walk would suddenly be unable to continue walking, or when seated would be unable to get up to answer the door.

'Off' periods usually come on gradually, but occasionally can be more sudden. When they come on suddenly, some people have compared this 'on/off' effect to that of a light switch being turned on and off.

But when a person freezes, it only affects certain movements. They may not be able to walk, for example, but they're still able to reach for a cup.

There are different ways of managing freezing and 'on/off' swings.

These are muscle movements that people with Parkinson's can't control. They can include twitches, jerks, twisting or writhing movements. Involuntary movements can affect various parts of the body, such as the arms, hands, legs, torso, jaw, face and neck.

There are different types of involuntary movements, and when and how often they appear can be different for each person with Parkinson's. Some people can have involuntary movements for most of the day. Others may only have them after taking their medication, or just before the next dose is due.

People with Parkinson's can also experience this side effect when levodopa is at its highest level in the bloodstream (sometimes called 'peak dose'), and the dopamine levels in their brains are at their highest. Dopamine is a chemical messenger made in the brain. The symptoms of Parkinson's appear when dopamine levels become too low.

Dyskinesia can vary in intensity from person to person. You might not feel too affected by mild dyskinesia, or might even be unaware of them, even though they might be visible to another person. Others may experience more severe dyskinesia, which can prevent them from carrying out simple tasks. For example, they might make walking difficult or impossible, and can sometimes affect talking.

Because dyskinesia causes people to move around so much, it can sometimes cause weight loss. If you're worried about this, speak to your GP, specialist or Parkinson's nurse. They can refer you to a dietitian, who will be able to help you maintain a healthy weight.

The term 'motor fluctuations' refers to when you go from having good control over your Parkinson's symptoms to having less control. This change can happen slowly or quickly.

Motor fluctuations usually happen when levodopa is wearing off, but they can happen at other times too.

Lots of people with Parkinson's experience motor fluctuations or involuntary movements after a few years of levodopa treatment. Some people may develop them earlier, especially if they're on a high dose of levodopa.

No one knows for sure why motor fluctuations and involuntary movements happen, but researchers think it's connected to the way levodopa stimulates the brain cells to produce dopamine.

Tremors can sometimes be mistaken for dyskinesia because they share similar physical features. Both dyskinesia and tremor are uncontrollable movements. But tremor is a symptom of Parkinson's, while dyskinesia is a side effect of levodopa.

The causes of tremor and dyskinesia, and the types of movement they each produce, are also different.

However, it's also possible to experience both tremors and dyskinesia at the same time.

Key differences between dyskinesia and tremor:

  • Tremor is a common early symptom of Parkinson's, whereas dyskinesia develops after years of someone taking Parkinson's medication. Some people may develop dyskinesia earlier, especially if they're on a high dose of levodopa
  • Tremor is rhythmic in movement, while dyskinesias are more unsteady and disorganised.
  • Notice what happens when you move a limb. Movement usually lessens or stops tremor, whereas it will normally increase dyskinesia.

If you think you're experiencing dyskinesia or are unsure if it's a tremor, speak to your specialist or Parkinson's nurse.

You should give them as much detail as possible about how movements are affecting you. This will help them to identify whether you have dyskinesia, or if it's another Parkinson's symptom, and manage the issue in the right way.

Motor fluctuations and involuntary movements can be difficult to treat. This is because if you take a lower dose of levodopa to reduce involuntary movements, your Parkinson's symptoms may not be as well controlled and you may experience more wearing off. 

If you develop motor fluctuations, talk to your specialist or Parkinson's nurse as soon as possible. They will advise you on what changes you can make to your drug regime to balance treating the motor problems with controlling your Parkinson's symptoms.

Clinical guidelines say your specialist should discuss your individual circumstances with you, and offer a choice of drugs to take together with levodopa to try to improve your motor symptoms.

They may also give you advice on avoiding 'peaks and troughs' in doses of levodopa. This might include taking smaller and more frequent doses of levodopa but keeping the overall amount the same. You may be advised to change to a different type of levodopa that helps even out levels in your bloodstream. You could also take it in another format. For example, by intestinal gel.


Apomorphine is a type of dopamine agonist which comes in liquid form. It's often used when pills or capsules no longer work well enough to control Parkinson's symptoms on their own. It can be used alone, but is often prescribed with levodopa medication to help it work better.

Find out more: see our webpage on drug treatments for Parkinson's.


For some people with Parkinson's, protein (which is found mainly in meat, fish, eggs, cheese, beans and pulses) seems to interfere with how well the body absorbs levodopa.

Because of this, you may benefit from taking your medication 30 to 60 minutes before you eat a meal to allow the medication time to start working.

Constipation can affect how well the body absorbs medication, making it less effective. Many people with Parkinson's experience constipation. This can be caused by Parkinson's symptoms, medication or other issues, such as difficulties with swallowing. 

Talk to your specialist or Parkinson's nurse about the timing of your medication. They can also refer you to a dietitian for specialist advice.

Find out more: see our webpage on diet and Parkinson's.


Deep brain stimulation

Deep brain stimulation (DBS) is a type of surgery used to treat Parkinson's. It can be effective in helping to improve motor symptoms.

DBS isn't suitable for everyone but it may be an option for people whose symptoms are no longer controlled by the best available medication. It may also be used for people who are experiencing involuntary movements.

DBS can help increase the amount of time you're in the 'on' state. This can mean that you're able to reduce your Parkinson's medication, and can help reduce side effects, such as involuntary movements.

Like any surgery, there are potential risks to having DBS. Talk to your specialist to find out more.

Managing stress

Stress may increase motor fluctuations and involuntary movements, so it's important to try to find ways of staying relaxed. You could try complementary therapies, such as massage, physical activity or exercise, such as tai chi or yoga, or breathing exercises. 

If you're frequently highly stressed or anxious, ask your specialist or Parkinson's nurse for advice on managing these conditions.

If you find dealing with people's reactions to your involuntary movements stressful of embarrassing, it may be worth explaining to those around you that the side effects are part of your condition, and they shouldn't be alarmed or concerned if they happen.

Find out more: see our webpage on anxiety.


Making the most of 'on' time

If you start to experience your medication wearing off, it's important that your drug regime is managed so you can make the most of your 'on' time. This becomes more complicated if you also begin to have involuntary movements.

You might have to decide on a compromise between more 'on' time with involuntary movements, or more 'off' time with other Parkinson's symptoms.

Many people tend to prefer more 'on' time, even with the dyskinesia, but everyone is different and you should discuss your options with your specialist or Parkinson's nurse.

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Coping with dyskinesia

"It's almost as if I've forgotten how to walk," says Bob. "I go from day to day trying to change different things with my walking to improve it. 

"I've been using this walker for about a year now and it's really made people want to help me more."

Watch our short film to hear from Bob about his experience of using a walker.

Living with Parkinson's and wearing off - Paula's story

Paula shares how her Parkinson's symptoms impact her everyday life, and how 'wearing off' affects her.

Last updated

Next update due 2025 

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