Sinemet availability

Merck Sharp & Dohme Limited (MSD) have shared that most Sinemet products are back in stock, they include:

  • Sinemet CR 50mg/200mg 6x10 tablets
  • Sinemet 10mg/100mg 10x10 tablets
  • Sinemet 12.5mg/50mg 9x10 tablets
  • Sinemet 25mg/250mg 10x10 tablets

However, there are still some intermittent supply issues with Sinemet Plus 25mg/100mg 10x10 tablets and Sinemet half CR 25mg/100mg 6x10 tablets. These should be back in supply at the end of October 2019.

Will this affect me?

If you take Sinemet Plus 25mg/100mg or Sinemet half CR 25mg/100mg your pharmacist may be unable to give you your full prescription.

However, there are generic versions of Co-careldopa, the active ingredient in Sinemet, available in a range of strengths.

Your GP or pharmacist can discuss this with you and should be able to offer you a suitable alternative.

Keeping you informed

We continue to receive regular updates from MSD, the company that manufactures Sinemet, letting us know about the supply issues and action they're taking to ensure Sinemet is available for people with Parkinson's across the UK.

We will continue to share further updates on Sinemet availability as we receive them.

Brexit preparations

MSD have also shared this statement about their Brexit preparations with us.

"We are working hard to make sure we are prepared for all Brexit scenarios, this includes:

  • re-routing of our supply chain
  • building a minimum of six weeks additional stock for medicines that enter the UK via Europe
  • working closely with partners across our supply and logistics chain to ensure those who support the manufacturing of our medicines in the UK have their own Brexit contingency plans in place 

"Unexpected delays can arise in complex manufacturing operations. MSD has a broad network of manufacturing facilities globally, and timely delivery of our medicines to patients and providers is always our key priority.

"However, we believe that the decisions we have implemented will help ensure that MSD's supply will not be negatively impacted once the UK formally leaves the EU."

Changes to 3 Sinemet products

MSD has taken action to stop this ongoing supply issue and has decided to move the manufacturing of 3 Sinemet products to another site, where they hope to provide a more consistent supply.

This means the look of these products will change, from round to oval. However, the tablets contain the same ingredients and should work as they do now. They will just look different.

The 3 products that will change their appearance from early May 2019 are below.

Presentation (co-careldopa)

Previous tablet appearance

Updated tablet appearance

Sinemet 10mg/100mg

Light blue round tablet marked 647, no score

Dark blue scored oval tablet marked 647

Sinemet 25mg/250mg

Light blue round tablet marked 654, no score

Dark blue scored oval tablet marked 654

Sinemet Plus 25mg/100mg

Yellow round tablet marked 650, no score

Yellow scored oval tablet marked 650


When will the tablets change?

These new look tablets will start to be used from early May 2019. However, some pharmacies may continue to dispense the round tablets until their supplies have been depleted.

This may mean you receive round tablets for some time from your usual pharmacy.

They are still OK to be taken.  

Updates to Sinemet availability

This story was originally published in September 2018. It has been updated since to reflect the changing availability of Sinemet.

It was last updated on 16 October 2019 to reflect that there are some intermittent supply issues with Sinemet Plus 25mg/100mg and Sinemet half CR 25mg/100mg.

Get support

If you have any questions or concerns regarding your medication, or if you're unable to obtain Sinemet, you can discuss this with your GP, consultant, pharmacist or Parkinson's nurse.

You can also contact our helpline on 0808 800 0303.