PD Frontline: identifying genes in people with Parkinson's
The aim of the research is to find a large number of people who have small genetic changes in genes such as LRRK2 or GBA, which are known to be associated with Parkinson's.
These people may be invited to take part in future clinical trials of drugs that target these genes, including the world-first phase 3 research study of ambroxol, ASPro-PD.
People with Parkinson's who live in the UK and are aged between 18 to 90 years old.
Registering on the PD Frontline website, where you will be asked to complete an online consent form and a 10 minute survey.
The study team will assess the information provided in the survey, and you will be sent two sample collection kits if you're eligible to take part. This will be posted to you with pre-paid return packaging. You'll use these kits to provide saliva and blood samples at home.
These samples will be used to carry out genetic testing for genes that are associated with Parkinson's.
Once genetic testing is complete, the PD Frontline team will contact people who may be eligible for the ASPro-PD study, as well as other medical research studies, and let them know where to sign up to take part.
Find out more about the study on the PD Frontline website.
Please note, if you have already taken part in RAPSODI, you don't need to register for PD Frontline, as they are linked research trials. Participants of both RAPSODI and PD Frontline will be offered the same research and clinical trial opportunities.
Interested in taking part?
Register for the study on the PD Frontline website.
If you have problems accessing the website or have any questions, please email the research team at [email protected].
The PD Frontline team check their inbox daily and aim to respond to all emails within a week of receiving them.
How long will it take for my kit to arrive?
Up to 4 weeks. You will be emailed when the kit has been sent and when the research team have received your samples.
When will the genetic testing of my sample be completed?
There are several stages to sequencing the GBA gene, and the process is complex, so the timeline for receiving results can vary. The team is working as quickly as possible to return results and typically allows between 6 to 8 months for sequencing.
The research team apologises in advance for the delay and will contact you once your results are ready.
The deadline for taking part in this research is 1 January 2028.
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