TOPHAT - Trial of Ondansetron as a Parkinson's Hallucination Treatment

The aim of the research is to see whether ondansetron will effectively treat visual hallucinations in people with Parkinson's or Lewy Body Dementia (LBD). As this is an already licensed drug, if the research shows significant outcomes, ondansetron could be available for people with Parkinson's or LBD who experience hallucinations within the next few years.

Who

306 people diagnosed with Parkinson's or Lewy Body Dementia (LBD) who experience hallucinations at least once a week. You also need to not be taking apomorphine and be on a stable dose of your Parkinson's or LBD medication for 28 days before starting the research.

What

The first activity is a telephone call to discuss the research more fully, give your consent to take part and complete some questionnaires. This will be followed by a brief face to face screening visit to assess your Parkinson’s, take a blood sample and monitor your heart rhythm. This visit may take place either at your house or at your local research site.

Once all the results from this visit are reviewed, you may be invited to take part and will be randomised to either receive ondansetron or placebo tablets, which will be shipped to you via a courier.

For full information about the research:

Please read the Participant Information Sheet.

More research centres will be looking for participants and the details will be added to this website in the next few months.

Deadline
Funded by

Parkinson's UK

Research
  • Treatments or therapies
Locations
Location

Cornwall Partnership NHS Foundation Trust
The Kernow Building
Wilson Way
Redruth
TR15 3QE
United Kingdom

Contact

Richard Higgins, 

[email protected],

01209 204020

Location

Queen Elizabeth Hospital
Neurology Department
Stadium Road
London
SE18 4QH
United Kingdom

Contact

Lee Kieft - Advanced Clinical Practitioner

Tel: 0208 836 6925

Email: [email protected]

Location

Queen Elizabeth University Hospital
Clinical Trials Unit
1345 Govan Road
Glasgow
G51 4TF
United Kingdom

Contact

Shona McKay or Catriona McNeill

[email protected] or [email protected],

0141 451 8945

Location

Aneurin Bevan
Royal Gwent Hospital
13 Clytha Square
Newport
NP20 2EF
United Kingdom

Contact

Rhian Hughes

Email: [email protected]

Tel: 07973743343

Location

Besti Cadwaladr University Health Board
Clinical Research Office
Ysbyty Gwynedd
Bangor
LL57 2PW
United Kingdom

Contact

Julia Roberts

Email: [email protected]

Tel: 01248 383091

Location

Ninewells Hosptial
James Arrot Drive
Dundee
DD1 9SY
United Kingdom

Contact

Kate Ferguson

Email: [email protected]

Tel: 01382 423086

 

Location

University College London Hospital
Movement Disorder Centre
33 Queens Square
London
WC1N 3BG
United Kingdom

Contact

Angelina Manoharan

Email: [email protected]

Tel: 020 3448 8608

Location

Salford Royal NHS Foundation Trust
Stott Lane
Salford
M6 8HD
United Kingdom

Contact

Neurology Research Team

Email: [email protected]

Tel: 0161 206 0534

Location

Darent Valley Hospital
Darenth Wood Road
Dartford
DA2 8DA
United Kingdom

Contact

Charlotte Kamundi or Drinda Harrington

Email: [email protected] or [email protected]

Tel: 01322 424759

Location

Pennine Acute NHS Foundation Trust
Fairfield General Hosptial
Rochdale Old Road
Bury
BL9 7TD
United Kingdom

Contact

Due to COVID-19 there have been unexpected delays to this research opening.

If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.

Thank you for your patience.

Location

Queen Elizabeth Hospital
Gayton Road
King's Lynn
PE30 4ET
United Kingdom

Contact

Due to COVID-19 there have been unexpected delays to this research opening.

If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.

Thank you for your patience.

Location

Royal Bournemouth Christchurch Hospitals NHS Foundation Trust
Castle Lane
Bournemouth
BH7 7DW
United Kingdom

Contact

Due to COVID-19 there have been unexpected delays to this research opening.

If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.

Thank you for your patience.

Location

NHS Grampian
Royal Cornhill Hospital
Cornhill Road
Aberdeen
AB25 2ZH
United Kingdom

Contact

Julie Scott or Kirsten McClelland-Brookes

Tel: 01224 557568

Email: [email protected] or [email protected]

Location

Charing Cross Hospital
10 West Imperial Memory Unit
Fulham Palace Road
London
W6 8RF
United Kingdom

Contact

Suzan Byaruhanga

Tel: 0203 311 1718

Email: [email protected]

Location

Luton and Dunstable NHS Foundation Trust
Ground Floor Nova House
Lewsey Road
Luton
LU4 0DZ
United Kingdom

Contact

Yvynne Croucher or the neurology research team

Tel: 01582 718300

Email: [email protected] or [email protected]

 

Location

Addenbrooke's Hospital
Clinical Research Network Eastern
Hill Road
Cambridge
CB2 0QQ
United Kingdom

Contact

Aileen Nacorda

Email: [email protected]

Tel: 01223 274143

Location

North Tyneside Hosptial
Rake Lane
North Shields
NE29 8NH
United Kingdom

Contact

Hayley Mckie

Email: [email protected]

Phone: 01912 934087

Location

Peterborough City Hospital
Bretton Gate
Peterborough
PE3 9GZ
United Kingdom

Contact

Daniele Arcoria, Zoey Horne and Natalie Temple (Research Nurses): 

Email: [email protected]

Phone: 01733 673891 or 01733 673828

Location

Royal London Hospital
Department of Neurology
2nd floor
London
E1 1FR
United Kingdom

Contact

Dr Charles Marshall

Email: [email protected]

Tel: 020 7377 7000

Location

Christchurch Hosptial
Fairmile Road
Christchurch
BH23 2JX
United Kingdom

Contact

Rochelle Hernandez and Emma Gunter

Email:  [email protected] or [email protected] 

Tel: 0300 019 5136 or 0300 019 5284

Location

Betsi Cadwaladr University Health Board
North Wales Clinical Research Centre
Unit 5 Gwenfro
Wrexham
LL13 7YP
United Kingdom

Contact

Claire Watkins

Email: [email protected]

Tel: 03000 858033