TOP HAT: Trial of a licensed drug as a Parkinson's Hallucination Treatment
Research teams across the UK are investigating if ondansetron has a meaningful treatment effect on Parkinson's and Lewy Body Dementia hallucinations.
As this is an already licensed low-cost drug, if the research shows significant outcomes, ondansetron could be available for people with Parkinson's who experience hallucinations within the next few years.
306 people diagnosed with Parkinson's or Lewy Body Dementia (LBD) who experience hallucinations at least once a week. You also need to not be taking apomorphine and be on a stable dose of your Parkinson's or LBD medication for 28 days before starting the research.
The first activity is a telephone call to discuss the research more fully, and complete some questionnaires. This will be followed by a brief face-to-face visit to assess your Parkinson’s, take a blood sample, and monitor your heart rhythm.
If you are eligible to take part, you will either receive ondansetron or dummy medication tablets for 12 weeks, which will be shipped to you via a courier. The research team will maintain regular contact throughout to take assessments and let you know how much medication to take. This contact will be through telephone, video call, and face-to-face.
All face-to-face visits can take place either at your home or at your local study site, it's up to you.
For full information about the research:
Please read the Participant Information Sheet.
Want to take part in this research? Scroll down to find your nearest study site location below, click on the arrow and contact the relevant research team before 1 November 2022.
If you want to take part from home, just let the research team know.
Parkinson's UK
Cornwall Partnership NHS Foundation Trust
The Kernow Building
Wilson Way
Redruth
TR15 3QE
United Kingdom
Queen Elizabeth Hospital
Neurology Department
Stadium Road
London
SE18 4QH
United Kingdom
Queen Elizabeth University Hospital
Clinical Trials Unit
1345 Govan Road
Glasgow
G51 4TF
United Kingdom
Aneurin Bevan
Royal Gwent Hospital
13 Clytha Square
Newport
NP20 2EF
United Kingdom
Besti Cadwaladr University Health Board
Clinical Research Office
Ysbyty Gwynedd
Bangor
LL57 2PW
United Kingdom
Ninewells Hosptial
James Arrot Drive
Dundee
DD1 9SY
United Kingdom
University College London Hospital
Movement Disorder Centre
33 Queens Square
London
WC1N 3BG
United Kingdom
Salford Royal NHS Foundation Trust
Stott Lane
Salford
M6 8HD
United Kingdom
Darent Valley Hospital
Darenth Wood Road
Dartford
DA2 8DA
United Kingdom
Charlotte Kamundi or Drinda Harrington
Email: [email protected] or [email protected]
Tel: 01322 424759
Pennine Acute NHS Foundation Trust
Fairfield General Hosptial
Rochdale Old Road
Bury
BL9 7TD
United Kingdom
Due to COVID-19 there have been unexpected delays to this research opening.
If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.
Thank you for your patience.
Queen Elizabeth Hospital
Gayton Road
King's Lynn
PE30 4ET
United Kingdom
Due to COVID-19 there have been unexpected delays to this research opening.
If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.
Thank you for your patience.
Royal Bournemouth Christchurch Hospitals NHS Foundation Trust
Castle Lane
Bournemouth
BH7 7DW
United Kingdom
Due to COVID-19 there have been unexpected delays to this research opening.
If you would like to take part please email [email protected]. and the TOP HAT team will get in contact with you as soon as the research begins to recruit at the centre nearest you.
Thank you for your patience.
NHS Grampian
Royal Cornhill Hospital
Cornhill Road
Aberdeen
AB25 2ZH
United Kingdom
Julie Scott or Kirsten McClelland-Brookes
Tel: 01224 557568
Email: [email protected] or [email protected]
Charing Cross Hospital
10 West Imperial Memory Unit
Fulham Palace Road
London
W6 8RF
United Kingdom
Luton and Dunstable NHS Foundation Trust
Ground Floor Nova House
Lewsey Road
Luton
LU4 0DZ
United Kingdom
Yvynne Croucher or the neurology research team
Tel: 01582 718300
Email: [email protected] or [email protected]
Addenbrooke's Hospital
Clinical Research Network Eastern
Hill Road
Cambridge
CB2 0QQ
United Kingdom
North Tyneside Hosptial
Rake Lane
North Shields
NE29 8NH
United Kingdom
Peterborough City Hospital
Bretton Gate
Peterborough
PE3 9GZ
United Kingdom
Daniele Arcoria, Zoey Horne and Natalie Temple (Research Nurses):
Email: [email protected]
Phone: 01733 673891 or 01733 673828
Royal London Hospital
Department of Neurology
2nd floor
London
E1 1FR
United Kingdom
Christchurch Hosptial
Fairmile Road
Christchurch
BH23 2JX
United Kingdom
Rochelle Hernandez and Emma Gunter
Email: [email protected] or [email protected]
Tel: 0300 019 5136 or 0300 019 5284
Betsi Cadwaladr University Health Board
North Wales Clinical Research Centre
Unit 5 Gwenfro
Wrexham
LL13 7YP
United Kingdom
Royal Stoke University Hospital
University Hospitals of North Midlands NHS Trust, Research and Innovation
B Block Newcastle Road
Staffordshire
ST4 6QG
United Kingdom
Queen's Hospital
Barking, Havering and Redbridge University Hospitals NHS Trust
Neuro Research office, Neurophysiology Department, Orange Zone, Ground Floor
Romford
RM7 0AG
United Kingdom
Tatiana Pogreban
Email: [email protected]
Elisa Visentin
Email: [email protected]
Telephone: 01708435000 ext 2079
John Radcliffe Hospital
Headley Way
Headington
OX3 9DU
United Kingdom
Sherwood Forest Hospitals NHS Foundation Trust
Kings Mill Hospital
Sutton In Ashfield
NG17 4JL
United Kingdom
Pennine Acute Hospitals NHS Trust
Ward 19 Clinical Research Unit, Fairfield General Hospital
Bury
BL9 7TD
United Kingdom
Parkinson’s Disease Research Team
Email: [email protected]
Telephone: 0161 778 2634 or 0161 778 2559
Royal Albert Edward Infirmary
Clinical Research office, The Hawthornes
Wigan Lane
Wigan
WN1 2NN
United Kingdom
Royal Devon and Exeter Hospital,
Rm 2.01 RILD Building,
Barrack Road
Exeter
EX2 5DW
United Kingdom
Scarborough Clinical Research Department
Floor 3 Woodlands House, Scarborough Hospital
Woodlands Drive
Scarborough
YO12 6QL
United Kingdom
Dr Edward Jones, Laith AlSaket and Kerry Elliott at Scarborough Research
Email: [email protected]
Telephone: 01723 342175
The RICE Centre
Royal United Hospital
Combe Park
Bath
BA1 3NG
United Kingdom