The Parkinson’s Progression Markers Initiative: How does Parkinson’s start and change?

Researchers around the world aim to identify how Parkinson’s starts and changes over time by obtaining information from people with certain risk factors for Parkinson's and people without Parkinson’s. This will ultimately help to develop new treatments, better clinical care, and potentially prevent Parkinson's.

Who

You may be eligible to participate if you fit the criteria of one of the following groups:

• Aged 60+ and are first-degree family members (parent, child, sibling) of a person with Parkinson’s,
• Aged 60+ who act out their dreams while asleep or who have a genetic mutation linked to PD or who experience sustained smell loss,
• Aged 56+ who haven’t been diagnosed with Parkinson’s and no known risk

What

You will be asked to visit your local research centre to discuss the opportunity and see if you are eligible to take part.

The study will then follow you over a number of years. You will be required to attend 4 study visits in the first year and 2 visits in the second year. At each visit, you will complete assessments such as physical and neurological exams, memory tests and brain scans.

Once you are enrolled in the study you will receive £80. Travel costs related to the study will also be reimbursed up to a reasonable amount for both study volunteers and a study companion.

For detailed inclusion criteria, please visit michaeljfox.org/ppmi

For more information, please read the Participant Information Sheet.