COBALT: Trial of a combination of 2 drugs as a Parkinson’s dementia treatment

Researchers across the UK are investigating if a combination of two drugs, an acetylcholinesterase inhibitor (AChEI) and memantine, can be used to treat Parkinson’s dementia and dementia with Lewy Bodies.

Who

300 people with Parkinson’s dementia or dementia with Lewy Bodies 
• who are aged over 55
• have been taking an acetylcholinesterase inhibitor (AChEI) medication (for example, Donepezil also called Aricept) for at least 12 weeks

All participants will be asked to take part with a trial partner such as a loved one or carer. 

What

You will be asked to take either the study drugs or a placebo drug for 52 weeks.

 
You will take part in 3 in-person visits at your local research hospital or at home.
• These in-person visits will involve blood tests, surveys, and physical assessments 
•  The length of each visit will be around 2 hours  
•  Travel expenses will be reimbursed for these visits 
 

You will take part in 5 telephone consultations.  
• These calls should last between 10 and 20 minutes 

For more information, please read the participant information sheets below:
•  For people with Parkinson’s
•  For trial partners, i.e. carers and loved ones

Interested in taking part?

Scroll down to find your nearest study site location, click on the arrow and contact the relevant research team. 

If you have any questions please contact the COBALT trial team by email at [email protected].

The deadline for taking part in this research is 31 March 2024. 

Deadline
Funded by

National Institute for Health Research – Health Technology Assessment

Research
  • Treatments or therapies
Locations
Location

Imperial Centre for Translational and Experimental Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital
Du Cane Road
London
W12 0HS
United Kingdom

Contact

Paul Edison

Phone: 07785541923

Email: [email protected]

Location

Cambridgeshire and Peterborough NHS Foundation Trust, Elizabeth House
Fulbourn Hospital, Fulbourn,
Cambridge
CB21 5EF
United Kingdom

Contact

Vandana Menon

Phone: 01954 712252

Email: [email protected]

Location

Cornwall Partnership NHS Foundation Trust, Carew House, Beacon Technology Park
Dunmere Road,
Bodmin
PL31 2QN
United Kingdom

Contact

Vandana Mate

Phone: 01208 844340

Email: [email protected]

Location

NHS Fife, Springfield House,
Cupar
KY15 5UP
United Kingdom

Contact

Nancy Attalla

Phone: 01383 623623

Email: [email protected]

Location

NHS Lanarkshire,
14 Beckford Street,
Hamilton
ML3 0TA
United Kingdom

Contact

Andrew Donaldson

Phone: 01236 784084

Email: [email protected]

Location

NHS Greater Glasgow and Clyde, J B Russell House, Gartnavel Royal Hospital,
1055 Great Western Road,
Glasgow
G12 0HX
United Kingdom

Contact

Eric Jackson

Phone: 0141 232 1300

Email: [email protected]

Location

North Bristol NHS Trust, Southmead Hospital,
Southmead Road,Westbury on Trym,
Bristol
BS10 5NB
United Kingdom

Contact

Elizabeth Coulthard

Phone: 0117 4147801

Email: [email protected]

Location

Nottinghamshire Healthcare NHS Foundation Trust, The Resource, Trust HQ,
Duncan Macmillan House, Porchester Road,
Nottingham
NG3 6AA
United Kingdom

Contact

Sarah Wilson

Phone: 0115 924 9924

Email: [email protected]

Location

Tees, Esk and Wear Valleys NHS Foundation Trust, Trust Headquaters,
West Park Hospital, Edward Pease Way,
Darlington
DL2 2TS
United Kingdom

Contact

Sabrina Leigh-Hunt

Phone: 0160 9763438

Email: [email protected]

Location

South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital,
Monks Orchard Road,
Beckenham
BR3 3BX
United Kingdom

Contact

Dag Aarsland

Phone: 0047 9755804

Email: [email protected]

Location

Southern Health NHS Foundation Trust, Tatchbury Mount Hospital
Calmore
Southampton
SO40 2RZ
United Kingdom

Contact

Jay Amin

Phone: 02380 475206

Email: [email protected]

Location

Kent and Medway NHS and Social Care Partnership Trust,Maidstone Community Mental Health Services for Older People,
Bay Tree House, Hermitage Lane,
Maidstone
ME16 9PH
United Kingdom

Contact

Joanne Rodda

Phone: 01622 726899

Email: [email protected]

Location

Devon Partnership NHS Trust, Wonford House Hospital,
Dryden Road,
Exeter
EX2 5AF
United Kingdom

Contact

Louise Allan

Phone: 01392 726025

Email: [email protected]

Location

Norfolk and Suffolk NHS Foundation Trust, Helleson Hospital,
Drayton High Road
Norwich
NR6 5BE
United Kingdom

Contact

Chris Fox

Phone: 01603 421421

Email: [email protected]

Location

Sheffield Health and Social Care NHS Foundation Trust, Fulwood House,
Old Fulwood Road,
Sheffield
S10 3TH
United Kingdom

Contact

Aparna Mordekar

Phone: 0114 2718320

Email: [email protected]

Location

Barking, Havering and Redbridge University Hospitals NHS Trust, Queens Hospital
Rom Valley Way,
Romford
RM7 0AG
United Kingdom

Contact

Alberto Cifelli

Phone: 0208 983 8000

Email: [email protected]

Location

Gloucestershire Health and Care NHS Foundation Trust, Edward Jenner Court,
1010 Pioneer Avenue, Gloucester Business Park,
Gloucester
GL3 4AW
United Kingdom

Contact

Tarun Kuruvilla

Phone: 01242 634460

Email: [email protected]

Location

The Newcastle upon Tyne NHS Foundation Trust, Freeman Hospital,
Freeman Road, High Heaton,
Newcastle upon Tyne
NE7 7DN
United Kingdom

Contact

Alison Yarnall

Phone: 0191 208 1279

Email: [email protected]

Location

Sussex Partnership NHS Foundation Trust, Trust HQ, Swandean Hospital,
Arundel Road
Worthing
BN13 3EP
United Kingdom

Contact

Naji Tabet

Phone: 0189 2603107

Email: [email protected]

Location

Oxford Health NHS Foundation Trust, Warneford Hospital,
Warneford Lane,Headington,
Oxford
OX3 7JX
United Kingdom

Contact

Vanessa Raymont

Phone: 01865 613147 

Email: [email protected] 

Location

University College London NHS Trust,
250 Euston Road
London
NW1 2PG
United Kingdom

Contact

Rimona Weil

Phone: 02034483048

Email: [email protected]

Location

NHS Lothian, NHS Lothian Headquarters,Waverley Gate,
2-4 Waterloo Place,
Edinburgh
EH1 3EG
United Kingdom

Contact

Gordon Duncan

Phone: 0131 537 3804

Email: [email protected]

Location

Surrey & Borders Partnership NHS Foundation Trust, R&D Department,
Two Bridges, Guildford Street,
Chertsey
KT16 9AU
United Kingdom

Contact

Ramin Nilforooshan

Phone: 01372 216584

Email: [email protected]

Location

South West London & St George’s Mental Health Trust, Barnes Hospital
South Worple Way, Barnes,
London
SW14 8SU
United Kingdom

Contact

Robert Lawrence

Phone: 07899 921703

Email: [email protected]