COBALT: Trial of a combination of 2 drugs as a Parkinson’s dementia treatment
Researchers across the UK are investigating if a combination of two drugs, an acetylcholinesterase inhibitor (AChEI) and memantine, can be used to treat Parkinson’s dementia and dementia with Lewy Bodies.
300 people with Parkinson’s dementia or dementia with Lewy Bodies
• who are aged over 55
• have been taking an acetylcholinesterase inhibitor (AChEI) medication (for example, Donepezil also called Aricept) for at least 12 weeks
All participants will be asked to take part with a trial partner such as a loved one or carer.
You will be asked to take either the study drugs or a placebo drug for 52 weeks.
You will take part in 3 in-person visits at your local research hospital or at home.
• These in-person visits will involve blood tests, surveys, and physical assessments
• The length of each visit will be around 2 hours
• Travel expenses will be reimbursed for these visits
You will take part in 5 telephone consultations.
• These calls should last between 10 and 20 minutes
For more information, please read the participant information sheets below:
• For people with Parkinson’s
• For trial partners, i.e. carers and loved ones
Interested in taking part?
Scroll down to find your nearest study site location, click on the arrow and contact the relevant research team.
If you have any questions please contact the COBALT trial team by email at [email protected].
The deadline for taking part in this research is 30 September 2024.
National Institute for Health Research – Health Technology Assessment
Imperial Centre for Translational and Experimental Medicine, Imperial College Healthcare NHS Trust, Hammersmith Hospital
Du Cane Road
London
W12 0HS
United Kingdom
Cambridgeshire and Peterborough NHS Foundation Trust, Elizabeth House
Fulbourn Hospital, Fulbourn,
Cambridge
CB21 5EF
United Kingdom
Cornwall Partnership NHS Foundation Trust, Carew House, Beacon Technology Park
Dunmere Road,
Bodmin
PL31 2QN
United Kingdom
NHS Fife, Springfield House,
Cupar
KY15 5UP
United Kingdom
NHS Lanarkshire,
14 Beckford Street,
Hamilton
ML3 0TA
United Kingdom
NHS Greater Glasgow and Clyde, J B Russell House, Gartnavel Royal Hospital,
1055 Great Western Road,
Glasgow
G12 0HX
United Kingdom
North Bristol NHS Trust, Southmead Hospital,
Southmead Road,Westbury on Trym,
Bristol
BS10 5NB
United Kingdom
Nottinghamshire Healthcare NHS Foundation Trust, The Resource, Trust HQ,
Duncan Macmillan House, Porchester Road,
Nottingham
NG3 6AA
United Kingdom
Tees, Esk and Wear Valleys NHS Foundation Trust, Trust Headquaters,
West Park Hospital, Edward Pease Way,
Darlington
DL2 2TS
United Kingdom
South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital,
Monks Orchard Road,
Beckenham
BR3 3BX
United Kingdom
Southern Health NHS Foundation Trust, Tatchbury Mount Hospital
Calmore
Southampton
SO40 2RZ
United Kingdom
Kent and Medway NHS and Social Care Partnership Trust,Maidstone Community Mental Health Services for Older People,
Bay Tree House, Hermitage Lane,
Maidstone
ME16 9PH
United Kingdom
Devon Partnership NHS Trust, Wonford House Hospital,
Dryden Road,
Exeter
EX2 5AF
United Kingdom
Norfolk and Suffolk NHS Foundation Trust, Helleson Hospital,
Drayton High Road
Norwich
NR6 5BE
United Kingdom
Sheffield Health and Social Care NHS Foundation Trust, Fulwood House,
Old Fulwood Road,
Sheffield
S10 3TH
United Kingdom
Barking, Havering and Redbridge University Hospitals NHS Trust, Queens Hospital
Rom Valley Way,
Romford
RM7 0AG
United Kingdom
Gloucestershire Health and Care NHS Foundation Trust, Edward Jenner Court,
1010 Pioneer Avenue, Gloucester Business Park,
Gloucester
GL3 4AW
United Kingdom
The Newcastle upon Tyne NHS Foundation Trust, Freeman Hospital,
Freeman Road, High Heaton,
Newcastle upon Tyne
NE7 7DN
United Kingdom
Sussex Partnership NHS Foundation Trust, Trust HQ, Swandean Hospital,
Arundel Road
Worthing
BN13 3EP
United Kingdom
Oxford Health NHS Foundation Trust, Warneford Hospital,
Warneford Lane,Headington,
Oxford
OX3 7JX
United Kingdom
University College London NHS Trust,
250 Euston Road
London
NW1 2PG
United Kingdom
NHS Lothian, NHS Lothian Headquarters,Waverley Gate,
2-4 Waterloo Place,
Edinburgh
EH1 3EG
United Kingdom
Surrey & Borders Partnership NHS Foundation Trust, R&D Department,
Two Bridges, Guildford Street,
Chertsey
KT16 9AU
United Kingdom
South West London & St George’s Mental Health Trust, Barnes Hospital
South Worple Way, Barnes,
London
SW14 8SU
United Kingdom
Bradford District Care NHS Foundation Trust Research and Development Lynfield Mount Hospital
Heights Lane
Bradford
BD9 6DP
United Kingdom