CAN-PDP: Cannabidiol (CBD) for people with Parkinson's who experience hallucinations or delusions

Research teams across the UK aim to investigate whether CBD is an effective treatment for hallucinations and delusions.

Who

120 people with Parkinson’s who:

• are over 40 years old

• have experienced any symptoms of psychosis for at least one month. This could include seeing, hearing, or feeling things that aren’t there and mistaking objects for other things (hallucinations). For example, a pile of clothes might look like a dog. Symptoms could also include unusual thoughts, beliefs, or worries that aren't based on reality (delusions)

• have been taking any Parkinson’s medications for at least one month

• are not taking clozapine

• and have someone who can attend study visits with them

What

If you are eligible to take part, you will either receive the study treatment (CBD) or a placebo treatment (such as a sugar pill) for 12 weeks.

You will be asked to attend up to 6 visits. Some of these can take place over the telephone or online, and others will need to take place at your local research centre or at your home. Each visit will last between 1 and 3 hours. During the visits, you may be asked to give blood samples, complete surveys, or physical examinations.

You can also optionally take part in 2 MRI scans.

Find more information in the following participant information sheets:

• Read the participant information sheet for people with Parkinson’s.

• Read the participant information sheet for accompanying loved ones or carers.

Interested in taking part?

Scroll down to find your nearest study site location, click on the arrow and contact the relevant research team.

The deadline for taking part in this research is 1 March 2025.

If you have any questions, please contact the Research Team by email at [email protected].

More information

You can stay up to date with news from the study and meet the research team on Twitter @CANPDP_trial or Facebook at www.facebook.com/CAN.PDP

This is a phase 2 research study. Previous studies suggest that CBD may be useful in treating symptoms of psychosis, they also suggest that it is safe to use in older adults. Find out more about the different phases of medical research.

Deadline

1 March 2025

Funded by

Parkinson's UK

Research

Treatments or therapies

Locations

King’s College Hospital

Location

King's College Hospital, Denmark Hill
London
SE5 9RS
United Kingdom

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Contact

Sara Pisani