New research using gene therapy may prevent inherited form of Parkinson's

27 August 2009

Scientists in the US have genetically engineered monkeys to be free from some inherited diseases, which could provide a new way of helping people with the inherited form of Parkinson's.

What the study is about

The study, reported in the journal 'Nature' this week, was intended to help women who carry genetic diseases.

It involved transferring healthy DNA from the mother's egg cell into a donated egg, using an IVF procedure designed to stop the spread of inherited conditions. 

Children conceived by the technique would inherit DNA from 3 sources, their mother, the donor and their father, and would be free from mutations in the mitochondrial DNA which is passed down from mothers to children.  

What are mitrochondria?

Mitochondria are like batteries, providing energy for nerve cells in the brain, and ultimately keeping cells alive.

Research has shown that a few gene mutations associated with inherited Parkinson's decrease the energy produced within cells, which results in them losing their ability to work properly. This may lead to nerve cell death.

Minor changes in mitrochondrial DNA have been shown to increase the risk of developing Parkinson's.

Funding research into the role of mitochondria and Parkinson's

The Parkinson's Disease Society (PDS) is funding research into the role mitochondria may play in inherited Parkinson's.

Dr Frank Hirth, Senior Lecturer at King's College London, is currently looking at key factors which may lead to nerve cell death.

Dr Hirth commented:

"This interesting American research potentially provides a new way of helping people with inherited diseases.

"However, as only a small percentage of people are affected by inherited Parkinson's - up to 5%  - the benefits of this new technique will be limited."

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