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Change from Madopar to Stalevo.

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Trev12345
Change from Madopar to Stalevo.

Neuro changed my meds from 100/25 Madopar x 3 a day to 100/25/200 Stalevo x 3 a day... Been on them for a week now.

I've noticed my walking is so much worse dragging my foot more often, they make me feel sick/tired all day... Although it feels the dystonia in my hand has improved.

Has anyone not gotten on well with Stalevo with similar problems as me? And switched back to there old meds?

Think I may speak to my PD nurse on Thursday (when she is next available) and find out her thoughts.

Trev

anonymous

 

Hi Trev

A year or more ago Neuro & PD nurse suggested i progess to Stalevo.

So I might think it is a standard approach to move onto Stalevo rather than a personal one that fits, I refused because i couldn't see why I should move from something that is working to something that is unknown in its results for Myself.

I suggested trying  ''entacapone'' to ring the changes which is the 200mg part of stalevo Rather than removing ''madopar'' which works for me.

So i take Madopar and one 200mg dose of entacapone to run alongside  each dose of Madopar.

It may be worth suggesting trying this if you feel unhappy with stalevo after all it is you who is taking these Pills and not your neuro.

ron reed

Curious--I'm almost at the stage where you were nearly a year ago--I've been asked to make this switch and, other than Madopar availability, I'm not sure of the reason for doing so. Although the info is apparently scarce, I have read that a slight reduction in dosage should also happen. Did you switch back? Or perhaps try the "compromise" as mentioned by the individual who replied earlier? I have also tried, with limited success, to determine the differences between carbidopa and benseraside, which is the other change involved. Same type, but differences? (I'm at Madopar x 5 daily). Thanks

turnip

benserazide inhibits the enzyme that catalyzes the decarboxylation of levadop to dopamine.
cabidopa does exactly the same. they can't pass the blood-brain-barrier so stop levadopa being wasted outside the brain.
entacapone inhibits COMT which wastes levadopa by turning it into 3-omd.
i take madopar and and stalevo. entacapone turns your pee orange, which is mildly diverting for a while but. apart from that i find them all much the same.

cheers