Nrf2 - very interesting

Research Research discussion
1

http://www.sciencedaily.com/releases/2016/12/161226211253.htmmutant

"The scientists discovered that Nrf2 worked in different ways to help remove either mutant LRRK2 or alpha-synuclein from the cells. For mutant LRRK2, Nrf2 drove the protein to gather into incidental clumps that can remain in the cell without damaging it. For alpha-synuclein, Nrf2 accelerated the breakdown and clearance of the protein, reducing its levels in the cell."

2

Hi Drewster,
nrf2 probably plays a fundamental role is protecting neuronal cells from ROS and Ca disregulation.
Its an emerging field:
https://www.researchgate.net/publication/277251978_Vitamin_D_A_custodian_of_cell_signalling_stability_in_health_and_disease

Peter