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Exanatide

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Drewster

2013 to 2017 for a drug already widely used.

Fills those of us on the Parkinson's roller-coaster with no end of confidence.

The lack of funding will stop many a promising therapy reaching the shelves.

Sigh.

Research Parkinson's UK

Hi TeeHee, 

Exenatide, as well as other diabetes drugs, stimulate the GLP-1 receptors in the pancreas. This causes insulin to be released and so regulates blood sugar levels. 

GLP-1 receptors are also found in the brain, and lab-based experiments have suggested that activating them can boost the function of dopamine connections, have anti-inflammatory properties, improve energy production, and switch on cell survival signals.

At the moment, there is little evidence to suggest that dietary changes can significantly influence Parkinson's symptoms. Eating a balanced diet will improve general wellbeing, and may help people to manage some of their symptoms. 

Hope that helps, 

Annie

Parkinson's UK Research Team 

 

Drewster

Bastyr published the primary conclusions of their ongoing research earlier this year ...

Materials & Methods:

The goal of this ongoing natural history study is to identify modifiable lifestyle variables associated with rate of PD progression. The Patient-Reported Outcomes in PD (PRO-PD) is the primary outcome measure, ranging from 0 (asymptomatic) to 2500 (severe) to assess PD severity.

Pragmatic Results
After adjusting for age, income, Hoehn & Yahr, and gender, the mean score at diagnosis was 574, with an annual increase of 16 points per year. The FFQ revealed an association between improved outcomes and intake of fresh vegetables, fruits, nuts & seeds, non-fried fish, olive and coconut oil. Canned fruits and vegetables, cheese, ice cream, beef, chicken, and pasta were associated with statistically worse outcomes over time.There was a dose-dependent association between days per week of exercise and reduction in PRO-PD score over time, the benefit becoming statistically significant with three or more days per week. Of the activities listed, yoga was the most beneficial form of exercise. That “other” was also significant suggests individualized programs may also be effective. Supplements used by >10% of participants are listed here. After adjustments for age, income, HY, and gender, fish oil, coenzyme Q10, and vitamin D were the only three supplements to be associated with fewer PD symptoms over time. Iron and melatonin supplementation were associated with faster PD progression. Because poor sleep has been associated with PD progression, an exploratory analyses was performed to differentiate the impact of insomnia from melatonin, a common treatment for insomnia. The association with the melatonin went away after adjusting for insomnia.

CONCLUSIONS:

The foods most protective against PD progression are staples of the Mediterranean diet. While previous studies have linked dairy and beef intake to PD incidence, this is the first study to demonstrate an association between dairy and beef intake and PD progression. Patients should be encouraged to exercise 30 minutes per day for maximum benefit. Whether yoga can be standardized and exploited to slow PD progression deserves further attention. Individuals reporting consistent supplementation with fish oil, coenzyme Q10, and vitamin D have improved outcomes in a naturalistic setting.
This pragmatic natural history study offers the first evidence base for prescribing a Mediterranean diet, daily exercise, and targeted nutritional supplementation to patients with PD.

Drewster

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