very interesting and thought provoking.
So the forces of law and order keep the bad guys under control but eventually lose control in one difficult to police area which then slowly spreads.

A question for btb - would you say dementia was the result of the toxic alpha-syncs (great name for a street gang) moving in on other neighbourhoods (hippocampus?) or an effect of the irregularities of dopamine on these cells?

also would the scenario fit in with anti-inflamatory use?

Turnip........I don't know the answer to those questions. I suspect a comparison of the development of dementia in Alzheimers to that in PD will shed some light but I havn't read the relevant literature yet (if any).

Hi There,Ihave just read the posts onthis sight and wouldlike to give
you my insight into my parkinsons. I am a Cabinetmaker to trade,dealing
in high class furniture,which is motly hardwoods,African Walnut ,
Mahogany,Burma Teakand African Rosewood.This harwoods have to be finished
off by hand/sanding,which caused a lot of fine hardwood particles
of dust floating in the air,Rosewood dust is a cancer of the nose
agent,the old cabinetmakers would not wear a mask.I contracted
Chronic Rhinitis,which I had for 35 years,feeling miserable mosst
days.It was me that kept Kleenex afloat, When I developed Parkinsons
guess what,the Rhinitis has totally dissapeared,I feel there could be
a link,but I know this might be just a co-incidence,but how has the
Rhinitis completely gone,only for the Parkinsons to follow.Thanks.

Hi Blueeyes I take 400mgs of ibuprofen 3 x daily and i have not noticed any difference in symptoms and have not been able to reduce my meds i take 41 tabs per day sorry if this puts a negative thought in your head but what works for one does not always work for another I hope it is a solution for you good luck may be it will have some good effect for others ?

Hello Sky,

Try this link:

www,newscientist,com/rhinitis

I hope it works - links and I do not get on particularly well.

The article suggests that PWP are 3X more likely to have been troubled by allergic rhinitis. Something to do with the inflamation being linked to the onset of neuro-degenerative disorder.

Fits in with Lily's post re antihistamines.

Poor you. I am tempted to ask which do you prefer -chronic rhinitis or PD, but I wont!

Best wishes

www.newscientist.com/rhinitis

Very recent research using a progressing PD model in the rat has shown that caffeine can slow down the spread of the disease in the brain. So, a good reason to keep drinking black tea..

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease
http://www.ncbi.nlm.nih.gov/pubmed/22309831

i wonder how accurate the mouse and rat models are for neuroprotection? these animals have been injected with chemicals that mimic pd, but if the on-going pd process is selfperpetuating prion-like or immune-system driven then they might be completely worthless? my amateur feeling is that only tests on primates are reliable as it is only then that the progression is as it is in pd.

Trouble is Turnip, is that people tend to get even more upset when a primate is killed so that it's brain can be examined to evaluate the results of the experiment even more than they do when the same is done to a mouse or a rat

Reminds me - I need a new mouse mat